Using microfluidics to reconstruct a Huntington’s disease corticostriatal network, Virlogeux et al. identify recurrent pre- and postsynaptic alterations leading to global circuit dysfunctions and hypersynchrony. They further demonstrate that the genetic status of the presynaptic compartment determines integrity of the network.

Studying intracellular dynamics in neurons is crucial to better understand how brain circuitscommunicate and adapt to environmental changes. In neurons, axonal secretory vesicles underlievarious functions from growth during development to plasticity in the mature brain. Similarly,transport of mitochondria, the power plant of the cell, regulates both axonal development and synaptichomeostasis.

Comprendre les connexions descendantes - de la cognition vers la perception- pour des applications sur l’intelligence artificielle, c’est ce à quoi s’est attelée une équipe de chercheurs des laboratoires LPNC, LJK, LIG, Gipsa-Lab de l’Université de Grenoble, LIP6, de l’Université Pierre et Marie Curie, l’université de Nantes et la faculté de santé de Melbourne