GIN Seminar : Meaghan Creed (University of Maryland School of Medicine, Baltimore, USA)

on the October 11, 2018

11.30am at GIN - Amphi Serge Kampf

Seminar by Meaghan Creed (University of Maryland School of Medicine, Baltimore, USA) 11.30 am at GIN - Amphi Serge Kampf
Targeting the Ventral Pallidum to Treat Addictive Disorders

Abstract: Addiction is a disorder of behavioral symptoms including sensitization to drug-associated cues, negative affect and compulsive drug seeking. Cocaine-evoked synaptic plasticity in the reward system, particularly the nucleus accumbens (NAc) and its main output structure, the ventral pallidum (VP) drives drug-adaptive behavior. However, how information is integrated downstream of the NAc remains unclear. Here, we identify the ventral pallidum (VP) as a site of convergence of direct and indirect pathways from the NAc. Cocaine potentiated output of D1-MSNs, but weakened output of D2-MSNs, occluding LTP and LTD at these synapses, respectively. Restoring basal transmission at D1-MSN-to-VP synapses abolished locomotor sensitization, whereas restoring transmission at D2-MSN-to-VP synapses normalized motivational deficits. We further identified a non-canonical population of neurons in the VP that specifically constrain reward seeking in the face of aversive consequences, which is a hallmark feature of addiction. Our results support a model by which drug-evoked synaptic plasticity in the VP mediates diverse behavioral symptoms of addiction; targeting the VP with neuromodulation may provide novel therapeutic strategies for addictive disorders.

Meaghan Creed is invited by Sabrina Boulet.

Published on October 9, 2018

Practical informations


Institut des Neurosciences de Grenoble
Amphi Serge Kampf
Bâtiment Edmond J. Safra
Chemin Fortuné Ferrini,
Site Santé
38706 La Tronche Cedex